As the world is shifting from fossil fuel to alternative energy sources the total volume of biodiesel produced is increasing. It has caused overproduction of crude glycerol which is the byproduct of biodiesel and is harmful for the environment. The aim of the project was to study arylidene Meldrum’s acids as one of the possible crude glycerol utilization routes and to investigate their reactions. Utilization of overproduced crude glycerol as a solvent in organic chemistry agrees to the philosophy of Green Chemistry and eco-friendly thinking. Valuable compounds were synthesized using crude glycerol as a solvent. New method was developed and three completely new compounds were synthesized. The structures of products were proved with nuclear magnetic resonance spectroscopy method.