The work is aimed at the personalized diagnostics of pulmonary diseases. As a part of the work, a biomarker panel based on the determination of biomarkers generated from arachidonic acid or coupled with oxidative stress in the exhaled breath condensate was created. It was unambiguously proved that the developed panel allows differentiation of pulmonary diseases, asthma phenotyping, monitoring of pharmacotherapy and that it could enable quicker and more accurate diagnostics. An idea of constructing a biochip that would even more simplify the current diagnostics is sketched up as well. Finally, the work “discovered” the lipoxin receptor which may represent an interesting target for new drugs with anti-asthmatic effect that would enhance the natural defence of organism against inflammation.


Tereza Kačerová