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Novel Pediatric Cancer Therapy: Targeting Epigenetics to Induce Differentiation

Neuroblastoma (NB) is a deadly childhood cancer arising from immature nerve cells. One of the methods of treating NB is by inducing cell differentiation, the process of specializing to form a specific cell type. Inducing differentiation allows for better treatment …

Asparagus polysaccharide selectively inhibits myeloid-derived suppressor cells by inducing apoptosis

MDSCs are a group of heterogeneous cells which derived from immature bone marrow cells. They are the precursor cells of dendritic cell, macrophage and granulocyte. In tumor carrier’s body, they can strongly suppress the anti-tumor immune response. Other researchers found …

Molecular Diagnostics of Pulmonary Diseases Based on the Analysis of Exhaled Breath Condensate

The work is aimed at the personalized diagnostics of pulmonary diseases. As a part of the work, a biomarker panel based on the determination of biomarkers generated from arachidonic acid or coupled with oxidative stress in the exhaled breath condensate …

The potential of multi-pathway therapy replacing the multi-drug therapy in cancer treatment

Pharmacy has been frozen for ages at direct chemical exploitation of new compoundswhich caused fluctuating efficiencies, side effectsand costs. However, nature is so specified in how diseases and pathogens evolve, and so we have to be in drug development. Cancer …

Galactosemia screening using the Beutler method

This research paper focuses on implementation of classical galactosemia screening using the Beutler method. Classical galactosemia is a hereditary disease and is caused by the ability to break down galactose, a monosaccharide in lactose, thus causing toxic intermediates to accumulate. …

Active targeting of cysteine cathepsins with liposomes conjugated with cystatin C

Targeted drug delivery uses properties of tumour cells and microenvironment, and increases the concentration of drugs in cancer cells. This research aimed at assembling a liposome with cystatin C, capable of active targeting and encapsulating cytotoxic drugs. Cystatin C is …

Small non-coding RNA induced gene silencing of tetracycline resistance gene in E. coli

The aim of this project was to determine whether small non-coding RNAs (sRNAs) are able to silence, i.e. to shut down the activity of antibiotic resistance genes. If so, the bacteria would lose their resistance and the antibiotics would become …