RAD51 protein repairs highly toxic DNA damage via homologous recombination and protects replication forks from nucleolytic degradation. Recently, RAD51 mutations were identified in several tumor types. However, the mechanism of how these mutations contribute to tumorigenesis remains elusive. This work …
Biology
The role of RAD51 mutations in cancer development
RAD51 protein repairs highly toxic DNA damage via homologous recombination and protects replication forks from nucleolytic degradation. Recently, RAD51 mutations were identified in several tumor types. However, the mechanism of how these mutations contribute to tumorigenesis remains elusive. This work …